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KMID : 0352720130370030308
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Journal of Ginseng Research
2013 Volume.37 No. 3 p.308 ~ p.314
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Anti-obesity effects of black ginseng extract in high fat diet-fed mice
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Lee Mi-Ra
Kim Byung-Chan
Kim Ran
Oh Hyun-In
Kim Hyun-Kyoung
Choi Kang-Ju
Sung Chang-Keun
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Abstract
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Black ginseng is produced by a repeated steaming process. The aim of this study was to investigate the anti-obesity effects of black ginseng ethanol extract (BG-EE) in high fat (HF) diet-fed mice. Two groups were fed either a normal control (NC) diet or a HF diet (45% kcal fat). The other three groups were given a HF diet supplemented with 1% BG-EE, 3% BG-EE, and 5% BG-EE for 12 wk. The anti-obesity effects of the BG-EE supplement on body weight, the development of fat mass, and lipid mechanisms were assessed in obese mice. HF-induced hyperlipidemia, fat accumulation in the liver, and white adipose tissues were reduced after BG-EE supplementation. Total fecal weight and the amount of fecal fat excretion also were increased after BG-EE supplementation. These results suggest that BG-EE may be useful to ameliorate HF-induced obesity through the strong inhibition of fat digestion.
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KEYWORD
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Panax ginseng, Black ginseng, High fat diet, Obesity, Hyperlipidemia,
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